Inflammation and Health Risks

Scientists at the CCID have found a major link between poor oral health and complications associated with several significant medical conditions. The CCID offers oral health care services that may improve the outcome for the following patient groups:

Patients with Periodontal Disease. Periodontal disease is an inflammatory response to bacteria that reside within the gum tissue. Scientists at the CCID are working with the Thurston Arthritis Center, the Lineberger Comprehensive Cancer Center, and the UNC School of Pharmacy to develop new anti-inflammatory agents that will be effective in treatments for periodontal disease, Rheumatoid Arthritis, and other inflammatory disorders. Clinicians at the CCID have a strong active program in periodontal disease prevention and management using the latest and most effective therapies.

Patients with Coronary Heart Disease. Investigators at the CCID have recently demonstrated that periodontitis is a significant independent risk factor for the fatality and morbidity associated with coronary heart diseases such as atherosclerosis, myocardial infarction and stroke. Scientists at the CCID are trying to develop new and more effective anti-inflammatory treatments for periodontal disease and coronary heart disease, to lessen the risk for a fatal heart attack or stroke. Clinicians at the CCID provide treatments for periodontal disease to lessen the potential risk of coronary heart disease, and provide referrals to appropriate medical clinics for at risk patients.

Pregnant Women. Investigators at the CCID have discovered that periodontal infections appear to be a significant risk factor for delivery of preterm low birth weight children (PLBWC). Scientists at the CCID are working to discover the link between inflammation and premature labor and delivery to develop better ways of delivering prenatal care to at risk women. Clinicians at the CCID are working with pregnant women at both UNC and Duke University to reduce the likelihood of preterm delivery and low birth weight children, and lessen the risk of birth defects.

Patients with Diabetes. It is well established that diabetes is a risk factor for severe periodontal disease, coronary heart disease, atherosclerosis, stroke, increased infections, and limb amputation. Scientists at the CCID are investigating how oral inflammation may contribute to the development or severity of diabetes, and why patients with diabetes are more susceptible to these other inflammatory disorders. Clinicians at the CCID are working with diabetic patients to treat periodontal disease and lessen the medical risks associated with the disease.